Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048

Biosci Biotechnol Biochem. 2018 Sep;82(9):1647-1651. doi: 10.1080/09168451.2018.1482195. Epub 2018 Jun 4.

Abstract

This study evaluated the immunostimulative effect on bone marrow-derived dendritic cells (DCs) of adjuvant-active exopolysaccharide (EPS) produced by Leuconostoc mesenteroides strain NTM048. EPS stimulation increased IL-6, IL-10, IL-12, and retinal dehydrogenase (RALDH) gene expression levels and induced retinoic acid-synthesizing RALDH-active DCs, which play a crucially important role in controlling adaptive immune responses in mucosa.

Keywords: Exopolysaccharide; Leuconostoc mesenteroides; RALDH; adjuvant; dendritic cell.

MeSH terms

  • Adaptation, Physiological / immunology
  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Dendritic Cells / drug effects*
  • Dendritic Cells / metabolism
  • Interleukin-10 / genetics
  • Interleukin-12 / genetics
  • Interleukin-6 / genetics
  • Leuconostoc mesenteroides / metabolism*
  • Mice
  • Mucous Membrane / immunology
  • Mucous Membrane / metabolism
  • Polysaccharides / pharmacology*
  • Retinal Dehydrogenase / genetics

Substances

  • Adjuvants, Immunologic
  • Interleukin-6
  • Polysaccharides
  • Interleukin-10
  • Interleukin-12
  • Retinal Dehydrogenase