Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children

Nutrients. 2018 May 27;10(6):680. doi: 10.3390/nu10060680.

Abstract

In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (n = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old (n = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: n = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher (p < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.

Keywords: children; immune function; vitamin D.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • 25-Hydroxyvitamin D 2 / blood
  • Biomarkers / blood
  • Calcifediol / blood
  • Child
  • Child Nutritional Physiological Phenomena*
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Food, Fortified*
  • Humans
  • Immune System / immunology
  • Immune System / physiopathology*
  • Infant
  • Inflammation Mediators / blood
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control
  • Male
  • Nutrition Assessment
  • Nutritional Status*
  • Quebec
  • Respiratory Tract Infections / immunology
  • Respiratory Tract Infections / prevention & control
  • Seasons
  • Urban Health*
  • Vitamin D / administration & dosage
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / immunology
  • Vitamin D Deficiency / physiopathology
  • Vitamin D Deficiency / prevention & control*

Substances

  • Biomarkers
  • Inflammation Mediators
  • Vitamin D
  • 25-Hydroxyvitamin D 2
  • Calcifediol