Abstract
In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (n = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old (n = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: n = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher (p < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.
Keywords:
children; immune function; vitamin D.
Publication types
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Randomized Controlled Trial
MeSH terms
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25-Hydroxyvitamin D 2 / blood
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Biomarkers / blood
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Calcifediol / blood
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Child
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Child Nutritional Physiological Phenomena*
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Child, Preschool
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Cross-Sectional Studies
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Female
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Follow-Up Studies
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Food, Fortified*
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Humans
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Immune System / immunology
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Immune System / physiopathology*
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Infant
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Inflammation Mediators / blood
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Influenza, Human / immunology
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Influenza, Human / prevention & control
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Male
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Nutrition Assessment
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Nutritional Status*
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Quebec
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Respiratory Tract Infections / immunology
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Respiratory Tract Infections / prevention & control
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Seasons
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Urban Health*
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Vitamin D / administration & dosage
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Vitamin D / therapeutic use*
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Vitamin D Deficiency / blood
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Vitamin D Deficiency / immunology
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Vitamin D Deficiency / physiopathology
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Vitamin D Deficiency / prevention & control*
Substances
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Biomarkers
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Inflammation Mediators
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Vitamin D
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25-Hydroxyvitamin D 2
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Calcifediol