Lipid-polymer hybrid nanocarrier-mediated cancer therapeutics: current status and future directions

Neeraj K Garg; Nikunj Tandel; Rajesh S Jadon; Rajeev K Tyagi; Om P Katare

doi:10.1016/j.drudis.2018.05.033

Lipid-polymer hybrid nanocarrier-mediated cancer therapeutics: current status and future directions

Drug Discov Today. 2018 Sep;23(9):1610-1621. doi: 10.1016/j.drudis.2018.05.033. Epub 2018 May 29.

Authors

Neeraj K Garg¹, Nikunj Tandel², Rajesh S Jadon³, Rajeev K Tyagi⁴, Om P Katare⁵

Affiliations

¹ University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India; Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India. Electronic address: neerajombiotech@gmail.com.
² Institute of Science, Nirma University Ahmedabad, Gujarat 382481, India.
³ School of Studies, Jiwaji University, Gwalior 474002, India.
⁴ Biomedical Parasitology and Nano-immunology Lab, Amity Institute of Microbial Technology, Amity University, Noida, India; Department of Periodontics, College of Dental Medicine, Augusta University, Augusta, GA 30912, USA. Electronic address: rktyagi2@amity.edu.
⁵ University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.

PMID: 29857164
DOI: 10.1016/j.drudis.2018.05.033

Abstract

The new generation of nanoparticles (NPs) encompass attributes of lipids and polymers and are referred to as 'lipid-polymer hybrid nanoparticles' (LPHNPs). LPHNPs have helped shed light on the mechanisms involved in targeted and non-specific drug delivery. Research has also highlighted the opportunities and challenges faced by the use of nanomedicine as personalized therapies in oncology. Here, we review the development of LPHNPs as cancer therapeutics, focusing on the methods deployed for enhancing the targeting efficiency and applications of LPHNPs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / chemistry
Antineoplastic Agents / metabolism
Diffusion of Innovation
Drug Carriers*
Drug Compounding
Forecasting
Humans
Lipids / chemistry*
Medical Oncology / trends*
Nanomedicine / trends*
Nanoparticles*
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Polymers / chemistry*
Technology, Pharmaceutical / trends*

Substances

Antineoplastic Agents
Drug Carriers
Lipids
Polymers