NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct

Linn W Thrane; Emily A Berglund; James N Wilking; David Vodak; Joseph D Seymour

doi:10.1021/acs.molpharmaceut.8b00144

NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct

Mol Pharm. 2018 Jul 2;15(7):2614-2620. doi: 10.1021/acs.molpharmaceut.8b00144. Epub 2018 Jun 14.

Authors

Linn W Thrane^{1

2}, Emily A Berglund¹, James N Wilking¹, David Vodak³, Joseph D Seymour¹

Affiliations

¹ Department of Chemical and Biological Engineering , Montana State University , Bozeman , Montana 59717-3920 , United States.
² Department of Mechanical and Industrial Engineering , Montana State University , Bozeman , Montana 59717 , United States.
³ Bend Research Incorporated, Lonza , Bend , Oregon 97701 , United States.

PMID: 29856634
DOI: 10.1021/acs.molpharmaceut.8b00144

Abstract

Nuclear magnetic resonance (NMR) frequency spectra and T₂ relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T₁- T₂ magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet.

Keywords: NMR relaxometery; amorphous; crystalline; melt solidification; porous construct.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Chemistry, Pharmaceutical / methods*
Humidity
Magnetic Resonance Spectroscopy / methods*
Porosity
Silicon Dioxide / chemistry
Tablets
X-Ray Diffraction

Substances

Tablets
Silicon Dioxide