Construction of linkage maps with DNA markers for human chromosomes

R White; M Leppert; D T Bishop; D Barker; J Berkowitz; C Brown; P Callahan; T Holm; L Jerominski

doi:10.1038/313101a0

Construction of linkage maps with DNA markers for human chromosomes

Nature. 1985 Jan;313(5998):101-5. doi: 10.1038/313101a0.

Authors

R White, M Leppert, D T Bishop, D Barker, J Berkowitz, C Brown, P Callahan, T Holm, L Jerominski

PMID: 2981412
DOI: 10.1038/313101a0

Abstract

DNA markers and sampling of three-generation families can be used to construct complete linkage maps of human chromosomes. This is important in mapping disease loci and in determining the genetic or environmental component of a disease.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromosome Mapping*
Chromosomes, Human*
DNA Restriction Enzymes
Genetic Diseases, Inborn / genetics*
Genetic Linkage
Heterozygote
Humans
Pedigree
Recombination, Genetic

Substances

DNA Restriction Enzymes