Definition and diagnosis of small fiber neuropathy: consensus from the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology

Arq Neuropsiquiatr. 2018 Mar;76(3):200-208. doi: 10.1590/0004-282x20180015.

Abstract

The aim of this study was to describe the results of a Brazilian Consensus on Small Fiber Neuropathy (SFN). Fifteen neurologists (members of the Brazilian Academy of Neurology) reviewed a preliminary draft. Eleven panelists got together in the city of Fortaleza to discuss and finish the text for the manuscript submission. Small fiber neuropathy can be defined as a subtype of neuropathy characterized by selective involvement of unmyelinated or thinly myelinated sensory fibers. Its clinical picture includes both negative and positive manifestations: sensory (pain/dysesthesias/pruritus) or combined sensory and autonomic complaints, associated with an almost entirely normal neurological examination. Standard electromyography is normal. A growing list of medical conditions is associated with SFN. The classification of SFN may also serve as a useful terminology to uncover minor discrepancies in the normal values from different neurophysiology laboratories. Several techniques may disclose sensory and/or autonomic impairment. Further studies are necessary to refine these techniques and develop specific therapies.

Publication types

  • Consensus Development Conference

MeSH terms

  • Autonomic Pathways / pathology
  • Biopsy
  • Brazil
  • Electromyography / methods
  • Humans
  • Nerve Fibers, Unmyelinated / pathology
  • Skin / pathology
  • Small Fiber Neuropathy / diagnosis*
  • Small Fiber Neuropathy / etiology
  • Small Fiber Neuropathy / pathology*
  • Small Fiber Neuropathy / physiopathology