Objective: To review the research progress on protease-activated receptor 2 (PAR-2) in the pathogenesis of osteoarthritis (OA).
Methods: The relevant literature about the mechanism of PAR-2 in the occurrence and development of OA in recent years was extensively reviewed and comprehensively analyzed.
Results: Abnormal activation of PAR-2 plays an important role in responses to occurrence and development of OA. Through regulating production and releasing of a variety of cytokines (such as inflammatory factors, metabolic factors, pain factors, etc.), the PAR-2 can involve in pathophysiological progression of OA articular cartilage, subchondral bone, and synovial membrane, as well as occurrence and transmission of pain.
Conclusion: PAR-2 participation in the development of OA has been confirmed. However, since PAR-2 is complicated and widespread, it is necessary to study the specific role of PAR-2 and the interaction between various signal pathways in the progression of OA, and to elucidate the potential pathophysiological mechanisms of PAR-2 participating in the process of OA, in the hope of exploring the new targets for the effective control of OA.
目的: 综述蛋白酶激活受体 2（protease-activated receptor 2，PAR-2）在骨关节炎（osteoarthritis，OA）发病机制中的研究进展。.
方法: 广泛查阅近年国内外有关 PAR-2 在 OA 发生发展过程中作用机制的文献，并进行综合分析。.
结果: PAR-2 的异常激活在 OA 发生发展过程中发挥重要作用。激活的 PAR-2 可以通过调节炎性因子、代谢因子、致痛因子等的生成及释放，参与 OA 关节软骨、软骨下骨及滑膜的生理和病理变化以及疼痛的产生与传导。.
结论: PAR-2 参与 OA 的发生发展已被证实，但由于 PAR-2 的复杂性以及分布的广泛性，需对其在 OA 进程中的具体作用及各通路间的相互影响进行深入研究，阐明 PAR-2 参与 OA 病变过程的潜在病理生理机制，以期探索新的有效控制 OA 发生的作用靶点。.
Keywords: Osteoarthritis; cytokine; joint; pain; protease-activated receptor 2.