Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy

Yi Hong Ong; Jonah Padawer-Curry; Jarod C Finlay; Michele M Kim; Andreea Dimofte; Keith Cengel; Timothy C Zhu

doi:10.1117/12.2290727

Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy

Proc SPIE Int Soc Opt Eng. 2018 Mar:10476:104760Y. doi: 10.1117/12.2290727.

Authors

Yi Hong Ong^{1

2}, Jonah Padawer-Curry¹, Jarod C Finlay¹, Michele M Kim^{1

2}, Andreea Dimofte¹, Keith Cengel¹, Timothy C Zhu¹

Affiliations

¹ Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104.
² Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104.

Abstract

PDT efficacy depends on the concentration of photosensitizer, oxygen, and light delivery in patient tissues. In this study, we measure the in-vivo distribution of important dosimetric parameters, namely the tissue optical properties (absorption μ_a (λ) and scattering μ_s ' (λ) coefficients), photofrin concentration (c_photofrin), blood oxygen saturation (%S_tO₂), and total hemoglobin concentration (THC), before and after PDT. We characterize the inter- and intra-patient heterogeneity of these quantities and explore how these properties change as a result of PDT treatment. The result suggests the need for real-time dosimetry during PDT to optimize the treatment condition depending on the optical and physiological properties.

Keywords: blood oxygen saturation; diffuse reflectance; photodynamic therapy; tissue optical properties; total hemoglobin concentration.

Abstract

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