An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of Aβ42

Lishuang Zhou; Wenfeng Liao; Xia Chen; Han Yue; Saijuan Li; Kan Ding

doi:10.1016/j.carbpol.2018.05.022

An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of Aβ₄₂

Carbohydr Polym. 2018 Sep 1:195:643-651. doi: 10.1016/j.carbpol.2018.05.022. Epub 2018 May 7.

Authors

Lishuang Zhou¹, Wenfeng Liao², Xia Chen¹, Han Yue³, Saijuan Li³, Kan Ding⁴

Affiliations

¹ Glycochemistry and Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China.
² Glycochemistry and Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China. Electronic address: liaowenfengbl@163.com.
³ Glycochemistry and Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China; School of Pharmacy, Zunyi Medical University, 201 Dalian Road, Zunyi 563000, PR China.
⁴ Glycochemistry and Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China; School of Pharmacy, Zunyi Medical University, 201 Dalian Road, Zunyi 563000, PR China. Electronic address: dingkan@simm.ac.cn.

PMID: 29805023
DOI: 10.1016/j.carbpol.2018.05.022

Abstract

The β amyloid (Aβ) induced neurodegeneration is believed to be one of pathological mechanisms of Alzheimer's disease (AD). The inhibition of Aβ production or aggregation is one of the promising therapeutic strategies for anti-AD drug discovery. Here, a homogeneous neutral polysaccharide designated LBP1A1-1 with an average molecular weight of 45.0 kDa was purified from fruits of Lycium barbarum L. Its structure was characterized to possess a backbone of 1, 3-linked β-Galp, 1, 6-linked β-Galp, 1, 4-linked α-Glcp with branches substituted at C-3 position of 1, 6-linked β-Galp or C-6 position of 1, 3-linked β-Galp. The branches contained terminal (T)-linked β-Galp, T-linked α-Araf, T-linked β-Araf, 1, 5-linked α-Araf and T-linked β-Rhap. The in vitro experiments revealed that LBP1A1-1 could inhibit Aβ₄₂ production and impede Aβ₄₂ aggregation in a dose-dependent-manner without cytotoxicity. These results suggested that LBP1A1-1 might have the multiple potential for the treatment of AD.

Keywords: Alzheimer’s disease; Aβ(42); Lycium barbarum; Polysaccharide.