Ten Events That Defined Anthelmintic Resistance Research

Trends Parasitol. 2018 Jul;34(7):553-563. doi: 10.1016/j.pt.2018.05.001. Epub 2018 May 23.

Abstract

Fifty years after anthelmintic resistance in livestock parasites was first reported, the prevalence of resistance has increased globally, and is of increasing significance in animal industries. It is now timely to reflect on what we have learnt, how research has unfolded, and what we hope to learn in the future. This Opinion paper examines ten important research events that were pivotal in resistance research. The moments include the discovery, description, and diagnosis of parasite resistance, as well as important physiological and genetic findings, and the development of online tools to help manage resistance. Despite our efforts, resistance remains the greatest challenge in parasite control. The future directions for research, including people and funding, are discussed.

Keywords: anthelmintic resistance; cost of disease; diagnosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthelmintics* / pharmacology
  • Anthelmintics* / therapeutic use
  • Drug Resistance* / genetics
  • Helminthiasis, Animal / drug therapy
  • Helminthiasis, Animal / parasitology*
  • Helminths / drug effects
  • Helminths / genetics
  • Parasitology / economics
  • Parasitology / standards
  • Parasitology / trends
  • Research / economics
  • Research / trends*

Substances

  • Anthelmintics