Objective: To review the research progress of adipose-derived stem cells (ADSCs) in skin wound healing.
Methods: The recent experiments and clinical studies on the role of ADSCs in skin wound healing were extensively retrieved and analyzed. Additionally, possible mechanisms and novel application strategies were proposed.
Results: As confirmed by in vitro and in vivo experiments and clinical studies, ADSCs promote skin wound healing mainly by two mechanisms: differentiation to target cells that participate in skin wound healing and cytokines paracrine to promote proliferation and migration of various cell lines that are mandatory to promote skin wound healing. Moreover, scaffold materials and cell sheet technology may further add to the potency of ADSCs in promoting skin wound healing.
Conclusion: Remarkable progress has been made in the application of ADSCs in skin wound healing. Further studies are needed to explore the application methods of ADSCs.
目的: 综述脂肪间充质干细胞（adipose-derived stem cells，ADSCs）在皮肤创伤修复中的研究进展。.
方法: 广泛查阅近年来将 ADSCs 应用于皮肤创伤修复的相关文献，对 ADSCs 进行皮肤创伤修复的体外、体内及临床研究治疗效果、可能机制、最新应用技术进行综述。.
结果: 体外、体内及临床研究均证实，ADSCs 主要通过直接分化为皮肤创伤修复所需的靶细胞和间接旁分泌作用促进多种皮肤创伤修复所需细胞系的增殖与迁移来实现促进修复的作用。新兴支架材料、细胞膜片技术可进一步提高 ADSCs 促进创面愈合的能力。.
结论: ADSCs 促进皮肤创伤修复的研究取得了显著进展，而 ADSCs 的应用途径仍有待进一步研究。.
Keywords: Adipose-derived stem cells; research progress; skin wound; wound repair.