Hepatitis C genotype change after transplantation utilizing hepatitis C positive donor organs

R Adekunle; S Jonchhe; B Ravichandran; E Wilson; J Husson

doi:10.1111/tid.12925

Hepatitis C genotype change after transplantation utilizing hepatitis C positive donor organs

Transpl Infect Dis. 2018 Aug;20(4):e12925. doi: 10.1111/tid.12925. Epub 2018 Jun 13.

Authors

R Adekunle¹, S Jonchhe², B Ravichandran², E Wilson³, J Husson³

Affiliations

¹ Department of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
² University of Maryland School of Pharmacy, Baltimore, MD, USA.
³ Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

PMID: 29797655
DOI: 10.1111/tid.12925

Abstract

A shortage in organs for transplantation has led to the increased use of hepatitis C (HCV) infected donor organs for solid organ transplant recipients infected with HCV. However, the donor HCV genotype is not routinely checked or known prior to transplant. Here, we report 4 cases of genotype conversion after transplantation in patients receiving HCV infected donor organs. This change in genotype may potentially impact HCV progression as well as treatment choice for these patients.

Keywords: genotype; hepatitis C; transplantation.

Publication types

Case Reports

MeSH terms

Aged
Allografts / virology
Antiviral Agents / therapeutic use
Donor Selection / standards
End Stage Liver Disease / surgery*
End Stage Liver Disease / virology
Female
Genotype
Genotyping Techniques
Graft Rejection / prevention & control
Hepacivirus / drug effects
Hepacivirus / genetics*
Hepacivirus / isolation & purification
Hepatitis C / drug therapy
Hepatitis C / transmission*
Hepatitis C / virology
Humans
Liver / virology
Liver Transplantation / adverse effects*
Liver Transplantation / methods
Male
Middle Aged
Sustained Virologic Response

Substances

Antiviral Agents