Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia

A P Lykov; N A Bondarenko; O V Poveshchenko; A V Kabakov; M A Surovtseva; I I Kim; O V Kazakov; A F Poveshchenko

doi:10.1007/s10517-018-4112-z

Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia

Bull Exp Biol Med. 2018 May;165(1):121-126. doi: 10.1007/s10517-018-4112-z. Epub 2018 May 24.

Authors

A P Lykov¹, N A Bondarenko², O V Poveshchenko², A V Kabakov², M A Surovtseva², I I Kim², O V Kazakov², A F Poveshchenko²

Affiliations

¹ Research Institute of Clinical and Experimental Lymphology -Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. aplykov2@mail.ru.
² Research Institute of Clinical and Experimental Lymphology -Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

PMID: 29796803
DOI: 10.1007/s10517-018-4112-z

Abstract

We studied the effect of intramuscular injections of bone marrow mesenchymal stromal cells on microcirculation parameters in an ischemic limb of Wistar rats. It was shown that transplantation of mesenchymal stem cells with or without erythropoietin stimulates angiogenesis in the ischemic zone. An essential role in angiogenesis stimulation is played by cytokines and growth factors.

Keywords: critical limb ischemia; cytokines; erythropoietin; mesenchymal stem cells; microcirculation.

MeSH terms

Angiogenesis Inducing Agents / therapeutic use
Animals
Erythropoietin / therapeutic use*
Extremities / pathology
Ischemia / drug therapy*
Ischemia / therapy*
Male
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells / physiology*
Neovascularization, Physiologic / drug effects
Rats
Rats, Wistar

Substances

Angiogenesis Inducing Agents
Erythropoietin