Abstract
We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / pharmacology*
-
Anti-Bacterial Agents / toxicity
-
Biofilms / drug effects*
-
Hemolysis / drug effects
-
Humans
-
Methicillin-Resistant Staphylococcus aureus / drug effects*
-
Miconazole / analogs & derivatives*
-
Miconazole / chemical synthesis
-
Miconazole / pharmacology*
-
Miconazole / toxicity
-
Microbial Sensitivity Tests
Substances
-
Anti-Bacterial Agents
-
Miconazole