Role of GW182 protein in the cell

Int J Biochem Cell Biol. 2018 Aug:101:29-38. doi: 10.1016/j.biocel.2018.05.009. Epub 2018 May 20.

Abstract

GW182 proteins interact directly with the argonaute proteins and constitute key components of miRNA repressor complexes (miRISC) in metazoans. As argonautes are insufficient for silencing they recruit the GW182 s that act as scaffold proteins inducing downstream translational repression, target mRNA deadenylation and exonucleolytic mRNA degradation. Besides their role as part of repressor complexes inside the cell, they function in wide variety of cellular processes as highlighted in this review. The present review summarises and discusses in detail our current knowledge of the GW182 s and their role inside the cell.

Keywords: Ago; GW182; TNRC6; miRISC; miRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Argonaute Proteins / genetics*
  • Argonaute Proteins / metabolism
  • Autoantigens / genetics*
  • Autoantigens / metabolism
  • Cell Cycle / genetics
  • Circadian Rhythm / genetics
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Exoribonucleases / genetics*
  • Exoribonucleases / metabolism
  • Gene Expression Regulation, Developmental*
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Poly(A)-Binding Proteins / genetics
  • Poly(A)-Binding Proteins / metabolism
  • Protein Biosynthesis
  • Protein Domains
  • RNA Stability
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Signal Transduction

Substances

  • Argonaute Proteins
  • Autoantigens
  • MicroRNAs
  • PABPC1L protein, human
  • Poly(A)-Binding Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • TNRC6A protein, human
  • Exoribonucleases
  • poly(A)-specific ribonuclease