Channel current analysis estimates the pore-formation and the penetration of transmembrane peptides

Analyst. 2018 Jul 23;143(15):3540-3543. doi: 10.1039/c8an00243f.

Abstract

We measured the current signal of the transmembrane model peptides using the barrel-stave, toroidal pore, and penetration models in order to establish a precise assignment of the channel signals. In addition, we analyzed the spike signals to estimate the membrane penetration of model cell-penetration peptides of different lengths.

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / chemistry
  • Lipid Bilayers / chemistry*
  • Membrane Proteins / chemistry*
  • Peptides / chemistry*
  • Protein Conformation
  • Xenopus
  • Xenopus Proteins / chemistry

Substances

  • Antimicrobial Cationic Peptides
  • Lipid Bilayers
  • Membrane Proteins
  • Peptides
  • Xenopus Proteins
  • magainin 1 peptide, Xenopus