The clinical presentation and collateral pathway development of congenital absence of the internal carotid artery

J Vasc Surg. 2018 Oct;68(4):1054-1061. doi: 10.1016/j.jvs.2018.01.043. Epub 2018 May 19.

Abstract

Objective: The objective of this study was to investigate the clinical presentation, risks, and collateral pathway development of the congenital absence of the internal carotid artery (ICA).

Methods: Sixty-four patients (10 new patients and 54 patients from the relevant literature) were studied. Data on demographic, clinical, and radiologic features were collected, followed by an analysis of the risks associated with ICA agenesis.

Results: There were 31 male and 33 female patients whose ages ranged from 5 months to 75 years, with a mean age of 31.1 years. The range of clinical symptoms recorded included transient ischemic attack (17 patients), subarachnoid hemorrhage (12 patients), developmental delay (13 patients), asymptomatic (8 patients), and other symptoms (15 patients). All 64 patients presented with absence of unilateral or bilateral ICAs, as measured by cervical computed tomography angiography or magnetic resonance angiography. The carotid canal was absent in all patients on computed tomography of the base of the skull, and abnormal development of collateral circulation pathways was observed. Five patients presented with basilar artery dilation on angiography. Aneurysms were observed in the angiography results from 16 patients. Ten patients presented with variations in the ophthalmic artery origin (the ophthalmic artery originated from the ipsilateral middle meningeal artery in six patients and from the ipsilateral middle cerebral artery in four patients).

Conclusions: From analysis of our 10 cases of ICA agenesis and our review of the relevant literature, we conclude that young patients with ICA agenesis may present with developmental delay, subarachnoid hemorrhage, or other developmental abnormalities, whereas older patients most commonly present with transient neurologic events. Complications of carotid agenesis are related to specific anatomic subtypes and the resulting collateral circulation development.

Keywords: Agenesis; Computed tomography angiography; Congenital; Internal carotid artery; Risks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Asymptomatic Diseases
  • Carotid Artery, Internal / abnormalities*
  • Carotid Artery, Internal / diagnostic imaging
  • Carotid Artery, Internal / physiopathology
  • Cerebral Angiography / methods
  • Cerebrovascular Circulation*
  • Child
  • Child, Preschool
  • Collateral Circulation*
  • Computed Tomography Angiography
  • Developmental Disabilities / etiology
  • Female
  • Humans
  • Infant
  • Ischemic Attack, Transient / etiology
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Ophthalmic Artery / abnormalities
  • Ophthalmic Artery / physiopathology
  • Prognosis
  • Regional Blood Flow
  • Retrospective Studies
  • Risk Factors
  • Subarachnoid Hemorrhage / etiology
  • Vascular Malformations / complications
  • Vascular Malformations / diagnostic imaging
  • Vascular Malformations / physiopathology*
  • Young Adult