Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy

Curr Pharm Des. 2018;24(21):2432-2437. doi: 10.2174/1381612824666180516111939.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, leading to the second most likely cause of cancer-related deaths. Medical imaging is crucial in clinic for HCC screening and diagnosis. Due to the relatively high special resolution and excellent sensitivity, magnetic resonance imaging (MRI) by using magnetic nanoparticle-based contrast agents has been used so far in HCC imaging and staging, demonstrating great potential and promising in vivo applications. This review focuses on the use of different magnetic nanoparticles for construction of HCC nanoprobes for MR imaging and theranostic purpose.

Keywords: MRI; Magnetic nanoparticle; cancer; diagnosis; hepatocellular carcinoma; molecular imaging..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Hepatocellular / diagnostic imaging*
  • Carcinoma, Hepatocellular / drug therapy*
  • Contrast Media / chemistry
  • Contrast Media / therapeutic use*
  • Humans
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / drug therapy*
  • Magnetic Resonance Imaging
  • Magnetite Nanoparticles / chemistry*
  • Molecular Probes / chemistry
  • Molecular Probes / therapeutic use*

Substances

  • Contrast Media
  • Magnetite Nanoparticles
  • Molecular Probes