Biochemical markers of hypertension, prehypertension

Abstract

Objective: There are insufficient researches aimed at evaluating biochemical markers of mechanisms of formation of AH and lesion of target organs in hypertension and prehypertension. The aim of that research was to study the level of endothelial dysfunction markers and damage to the cardiovascular system in hypertension and prehypertension.

Patients and methods: A cross-sectional study was performed among 938 people aged 18 to 65 years. All respondents were surveyed, blood pressure measured, for glucose, cholesterol, interleukin-6, sFAS, LIGHT, hFABP, NT-ProBNP and an Endocan concentrations were tested. Depending on the level of blood pressure participants were splitted into groups with normotension, prehypertension and hypertension.

Results: Comparing the markers of inflammation, apoptosis and target organ damage in the prehypertensive group, the level of the LIGHT protein was Me=265.2pg/ml (Q₂₅-Q₇₅: 197.7-444.3), in the control group - Me=251.1pg/ml (Q₂₅-Q₇₅: 176.6-376.6), the Endocan level was Me=660.6pg/ml (Q₂₅-Q₇₅: 419.6-867.4) and in the control group Me=587.5pg/ml (Q₂₅-Q₇₅: 401.9-838.1). In the AH group, the level of the LIGHT Me=273.1pg/ml (Q₂₅-Q₇₅: 195.1-455.2), Endocan Me=668.2pg/ml (Q₂₅-Q₇₅: 434.8-977.3), heart-type fatty-acid-binding protein Me=2233.1pg/ml (Q₂₅-Q₇₅: 1518.4-3391.1) exceeded the control group.

Conclusion: Thus, the development of prehypertension and hypertension is characterized by an increase in the activity of biochemical markers of endothelial dysfunction and damage to target organs, more expressed in the presence of hypertension.

Keywords: Atteinte cardiovasculaire; Biochemical markers; Cardiovascular damage; Dysfonction endothéliale; Endothelial dysfunction; Hypertension; Marqueurs biochimiques.