Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report

Takashi Tokita; Takashi Kawahara; Yusuke Ito; Sohgo Tsutsumi; Koichi Abe; Kazuhiro Namura; Futoshi Sano; Koichi Shioi; Daiji Takamoto; Yasushi Yumura; Noboru Nakaigawa; Masahiro Yao; Hiroji Uemura; Hidefumi Wada; Yukio Tsuura; Kazuki Kobayashi

doi:10.1016/j.eucr.2018.03.006

Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report

Urol Case Rep. 2018 Mar 13:18:54-56. doi: 10.1016/j.eucr.2018.03.006. eCollection 2018 May.

Authors

Affiliations

¹ Department of Urology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
² Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.
³ Department of Urology, Yokohama City University Medical Center, Yokohama, Japan.
⁴ Department of Dermatology, Yokohama City University Hospital, Yokohama, Japan.
⁵ Department of Pathology, Yokosuka Kyosai Hospital, Yokosuka, Japan.

Abstract

We report a rare case of primary amelanotic malignant melanoma of the male urethra. A 65-year-old man with a urethral mass was referred to our hospital. A pathological diagnosis of a biopsy specimen revealed malignant melanoma. Thereafter, the patient underwent partial penectomy. The histopathological diagnosis was amelanotic malignant melanoma of the urethra. The patient had received DAV-Feron in an adjuvant setting; however, PET-CT revealed multiple metastasis. After receiving more than 10 cycles of nivolumab, the accumulation of FDG was no longer observed on PET-CT. The patient is currently free from recurrence at 20 months after nivolumab treatment.

Keywords: Inguinal lymphadenectomy; Melanoma; Nivolumab; Urethral neoplasm.

Publication types

Case Reports