Abstract
In our effort to find antioxidants from the higher fungi, we isolated three new compounds (1-3) with a known compound, spirobenzofuran (4), from the culture broth of Hericium coralloides. Bioassay-guided fractionation led to the isolation of these compounds, and we determined the chemical structures through spectroscopic methods. These compounds exhibited antioxidant activity in the range of IC50 values of 29-66 μM in the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging assay.
MeSH terms
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Antioxidants / isolation & purification
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Antioxidants / metabolism*
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Antioxidants / pharmacology*
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Bacteria / drug effects*
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Basidiomycota / metabolism*
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Benzofurans / chemistry
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Benzofurans / metabolism
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Benzofurans / pharmacology*
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Free Radical Scavengers / pharmacology*
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Microbial Sensitivity Tests
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Reactive Oxygen Species / metabolism
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Spiro Compounds / chemistry
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Spiro Compounds / metabolism
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Spiro Compounds / pharmacology*
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Sulfonic Acids / chemistry
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Sulfonic Acids / pharmacology
Substances
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Antioxidants
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Benzofurans
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Free Radical Scavengers
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Reactive Oxygen Species
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Spiro Compounds
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Sulfonic Acids
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spirobenzofuran