Optimization of orodispersible and conventional tablets using simplex lattice design: Relationship among excipients and banana extract

Sureewan Duangjit; Pakorn Kraisit

doi:10.1016/j.carbpol.2018.03.087

Optimization of orodispersible and conventional tablets using simplex lattice design: Relationship among excipients and banana extract

Carbohydr Polym. 2018 Aug 1:193:89-98. doi: 10.1016/j.carbpol.2018.03.087. Epub 2018 Mar 27.

Authors

Sureewan Duangjit¹, Pakorn Kraisit²

Affiliations

¹ Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
² Division of Pharmaceutical sciences, Faculty of Pharmacy, Thammasat University, Pathumthani, 12120, Thailand. Electronic address: pakorn54@tu.ac.th.

PMID: 29773401
DOI: 10.1016/j.carbpol.2018.03.087

Abstract

The objective of this study was focused on the optimization of the pharmaceutical excipients and banana extract in the preparation of orally disintegrating banana extract tablets (OD-BET) and conventional banana extract tablets (CO-BET) using a simplex lattice design. Various ratios of banana extract (BE), dibasic calcium phosphate (DCP) and microcrystalline cellulose (MCC) were used to prepare banana extract tablets (BET). The results indicated that the optimal OD-BET and CO-BET consisted of BE: DCP: MCC at 10.0, 88.8, 1.2, 10.0, 83.8: and 6.2, respectively. AFM demonstrated that the surface of BET with BE + MCC was smooth and compacted when compared to BET with BE + DCP + MCC and BE + DCP. FTIR and XRD showed a correlation in the results and indicated that no interaction of each ingredient occurred in the process of BET formulation. Therefore, the experimental design is potentially useful in formulated OD-BET and CO-BET by using only one design simultaneously.

Keywords: Banana extract; Dibasic calcium phosphate; Experimental design; Microcrystalline cellulose; Orally disintegrating tablets (ODT); Simplex lattice design.