New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum

Nat Prod Res. 2019 Dec;33(23):3343-3349. doi: 10.1080/14786419.2018.1475387. Epub 2018 May 17.

Abstract

Three new cembrane diterpenes, nephthecrassocolides A-B (1-2) and 6-acetoxy nephthenol acetate (3) along with three known compounds, 6-acetoxy-7,8-epoxy nephthenol acetate (4), epoxy nephthenol acetate (5) and nephthenol (6) were isolated from one population of Nephthea sp. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1-6 were evaluated.

Keywords: sp.; antifungal; cembrane; diterpene; soft coral.

Publication types

  • Video-Audio Media

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Drug Evaluation, Preclinical
  • Lagenidium / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Spectrometry, Mass, Electrospray Ionization
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Diterpenes