Cold Pressor Pain Response in Children With Cancer

J Pediatr Hematol Oncol. 2018 Jul;40(5):368-373. doi: 10.1097/MPH.0000000000001219.

Abstract

Objective: The goal of this study was to examine pain responses in pediatric patients with cancer.

Method: Children (ages 6 to 18) undergoing treatment for cancer (N=68) completed the cold pressor task.

Results: Average pain tolerance was 118.22 seconds (SD=101.18) and 40% of the children kept their hand in the water the entire 4-minute ceiling. On a 0 to 10 numeric rating scale, children reported a pain severity of 5.07 (SD=3.47) at their first report of pain, a pain severity of 5.94 (SD=3.54) at their maximum report of pain, and a pain severity of 5.33 (SD=3.72) at the time they reached pain tolerance. Children receiving chemotherapy agents (N=56) with possible neuropathic effects exhibited higher pain tolerance compared with children not receiving such treatments (N=10), β=0.84, SE=0.38, Wald χ1=4.88, P=0.027, hazard ratio=2.33, 95% confidence interval (1.10-4.92).

Conclusions: This study provides data on experimental pain responses in a sample of children undergoing cancer treatment and suggests that pain experience may be moderated by cancer treatment type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Agents* / administration & dosage
  • Antineoplastic Agents* / adverse effects
  • Child
  • Female
  • Humans
  • Male
  • Neoplasms* / drug therapy
  • Neoplasms* / physiopathology
  • Neuralgia* / chemically induced
  • Neuralgia* / physiopathology
  • Pain Measurement
  • Pain Perception*

Substances

  • Antineoplastic Agents