Abstract
We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects.
Keywords:
OSCC; berberine; miR-122; nanocarrier PC.
© 2018 The Author(s).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Berberine / chemistry
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Berberine / pharmacology*
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Cell Line, Tumor
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Cell Movement / drug effects
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Cell Proliferation / drug effects
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Cholesterol / chemistry
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Diffusion Chambers, Culture
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Drug Carriers*
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Drug Compounding / methods
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Drug Dosage Calculations
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Epithelial Cells / drug effects*
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Epithelial Cells / metabolism
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Epithelial Cells / pathology
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Humans
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MicroRNAs / genetics*
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MicroRNAs / metabolism
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Nanoparticles / chemistry
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Nanoparticles / metabolism*
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Nanoparticles / ultrastructure
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Polyethyleneimine / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Drug Carriers
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MIRN122 microRNA, human
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MicroRNAs
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Berberine
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Polyethyleneimine
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Cholesterol