Comparison of the Xpert Flu/RSV XC and Xpress Flu/RSV Assays

J Clin Microbiol. 2018 Jul 26;56(8):e00278-18. doi: 10.1128/JCM.00278-18. Print 2018 Aug.

Abstract

Molecular diagnostics for influenza and respiratory syncytial virus (RSV) have become commonplace, and various tests and systems have been cleared by the FDA for use in the United States. We performed a retrospective study to compare the Cepheid Xpress Flu/RSV assay with the Xpert Flu/RSV XC assay, using laboratory-developed tests (LDTs) as the reference method. The Xpress assay was 100% accurate compared to LDTs, whereas the Xpert Flu/RSV XC assay was 96.0% accurate. The Xpress test was determined to be faster and more sensitive than the XC assay.

Keywords: Cepheid; Xpert; influenza; molecular diagnostics; respiratory syncytial virus.

Publication types

  • Comparative Study

MeSH terms

  • Age Distribution
  • Humans
  • Influenza A virus / isolation & purification*
  • Influenza B virus / isolation & purification*
  • Influenza, Human / diagnosis
  • Molecular Diagnostic Techniques / methods*
  • Molecular Diagnostic Techniques / standards
  • Nasopharynx / virology
  • Respiratory Syncytial Virus Infections / diagnosis
  • Respiratory Syncytial Virus, Human / isolation & purification*
  • Respiratory Tract Infections / diagnosis*
  • Retrospective Studies
  • Sensitivity and Specificity
  • Time Factors