Matrix metalloproteinase-9 gene polymorphisms and their interaction with environment on subarachnoid hemorrhage risk

Tao Wang; Wanxing Fu; Shuang Song; Yanlong Han; Lihong Yao; Youkui Lu; Junshuai Zheng; Jing Wang

doi:10.1177/1535370218775042

Matrix metalloproteinase-9 gene polymorphisms and their interaction with environment on subarachnoid hemorrhage risk

Exp Biol Med (Maywood). 2018 May;243(9):749-753. doi: 10.1177/1535370218775042.

Authors

Tao Wang¹, Wanxing Fu², Shuang Song¹, Yanlong Han³, Lihong Yao¹, Youkui Lu⁴, Junshuai Zheng⁴, Jing Wang³

Affiliations

¹ 1 Department of Ultrasonography, the Affiliated Hongqi Hospital of Mudanjiang Medical University, Heilongjiang Province 157011, China.
² 2 Office of Student Affairs, School of Basic Medical Sciences of Mudanjiang Medical University, Heilongjiang Province 157011, China.
³ 3 Department of Biology, School of Basic Medical Sciences of Mudanjiang Medical University, Heilongjiang Province 157011, China.
⁴ 4 Department of Endocrinology Two, the first People's Hospital of Mudanjiang, Heilongjiang Province 157011, China.

Abstract

The current study aimed to investigate the relations of three single nucleotide polymorphisms of matrix metalloproteinase-9 gene, and single nucleotide polymorphisms-smoking interaction to subarachnoid hemorrhage risk. The optimal pattern of the interaction among single nucleotide polymorphisms and smoking was selected by generalized multifactor dimensionality reduction. The association between the three single nucleotide polymorphisms within the matrix metalloproteinase-9 gene was analyzed by logistic regression test. As well as genetic risk of subarachnoid hemorrhage interactions with smoking, the risk of subarachnoid hemorrhage in carriers with the rs3918242 (T) was significantly higher than in carriers carrying CC (genotype: CT + TT vs. CC), adjusted OR (95% CI) = 1.58 (1.25-2.03), and in carriers carrying rs17576- (genotype: AG + GG vs. AA), adjust OR (95% CI) = 1.62 (1.19-2.13). However, after adjusting for covariates, we did not find any direct association between rs17577 and subarachnoid hemorrhage risk. The generalized multifactor dimensionality reduction model shows a potential relation between rs3918242 and smoking risk for subarachnoid hemorrhage ( P = 0.0010). After covariates adjustment, current smokers with rs3918242-CT or TT genotype, compared to never-smokers with rs3918242-CC genotype, OR (95% CI) = 2.57 (1.74-3.46), have a higher subarachnoid hemorrhage risk. Our study showed that the rs3918242 (T) and rs17576 (G), the cross reaction between rs3918242 and smoking increased the risk of subarachnoid hemorrhage. Impact statement Matrix metalloproteinase-9 ( MMP-9) is a possible candidate gene for some diseases, including metabolic syndrome, stroke, coronary artery disease (CAD). But to date, limited data focused on the relationship between MMP-9 gene SNPs and SAH susceptibility. The purpose of this study was to evaluate SNPs of MMP-9 gene and their interaction with environmental factors with SAH risk based on a Chinese population.

Keywords: Subarachnoid hemorrhage; interaction; matrix metalloproteinase-9; single nucleotide polymorphisms; smoking.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Gene-Environment Interaction*
Genotype*
Humans
Male
Matrix Metalloproteinase 9 / genetics*
Middle Aged
Models, Genetic*
Polymorphism, Single Nucleotide*
Risk Factors
Smoking* / adverse effects
Smoking* / genetics
Subarachnoid Hemorrhage / genetics*

Substances

MMP9 protein, human
Matrix Metalloproteinase 9