Pemphigus is a potentially life-threatening, autoimmune blistering disease characterized by the presence of circulating antibodies against desmogleins, key components of the integrity of epidermal intercellular adhesion. However, in contrast to pemphigus vulgaris (PV) where mucosal lesions are classically present, pemphigus foliaceus (PF) there is only skin involvement without mucosal lesions. As an acquired form of pemphigus, pemphigus foliaceus is caused by immunoglobulin G (IgG) antibodies directed against desmoglein-1 (Dsg1) found in the granular layer of the epidermis.
Copyright © 2024, StatPearls Publishing LLC.