Ruthenium(II)-Catalyzed Positional Selective C-H Oxygenation of N-Aryl-2-pyrimidines

Tanumay Sarkar; Sourav Pradhan; Tharmalingam Punniyamurthy

doi:10.1021/acs.joc.8b00714

Ruthenium(II)-Catalyzed Positional Selective C-H Oxygenation of N-Aryl-2-pyrimidines

J Org Chem. 2018 Jun 15;83(12):6444-6453. doi: 10.1021/acs.joc.8b00714. Epub 2018 May 24.

Authors

Tanumay Sarkar¹, Sourav Pradhan¹, Tharmalingam Punniyamurthy¹

Affiliation

¹ Department of Chemistry , Indian Institute of Technology Guwahati , Guwahati 781039 , India.

PMID: 29761702
DOI: 10.1021/acs.joc.8b00714

Abstract

Efficient Ru-catalyzed regioselective C-H oxygenation of N-aryl-2-pyrimidines is described with aryl carboxylic acids in the presence of AgSbF₆ as an additive and Ag₂CO₃ as an oxidant. The reaction can be extended to alkyl, heteroaryl, and α,β-unsaturated carboxylic acids. The regioselectivity, broad substrate scope, and functional group tolerance are the significant practical advantages.

Publication types

Research Support, Non-U.S. Gov't