Niacin modulates macrophage polarization in Parkinson's disease

Chandramohan Wakade; Banabihari Giri; Aneeq Malik; Hesam Khodadadi; John C Morgan; Raymond K Chong; Babak Baban

doi:10.1016/j.jneuroim.2018.05.002

Niacin modulates macrophage polarization in Parkinson's disease

J Neuroimmunol. 2018 Jul 15:320:76-79. doi: 10.1016/j.jneuroim.2018.05.002. Epub 2018 May 4.

Authors

Chandramohan Wakade¹, Banabihari Giri², Aneeq Malik³, Hesam Khodadadi³, John C Morgan⁴, Raymond K Chong², Babak Baban⁵

Affiliations

¹ Charlie Norwood Veteran Affairs Medical Center, Augusta, GA, USA; Department of Physical Therapy, College of Allied Health Sciences, Augusta University Augusta, GA, USA. Electronic address: cwakade@augusta.edu.
² Department of Physical Therapy, College of Allied Health Sciences, Augusta University Augusta, GA, USA.
³ Department of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA, USA.
⁴ Parkinson's Foundation Center of Excellence, Movement Disorders, Program, Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
⁵ Department of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA, USA; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: bbaban@augusta.edu.

PMID: 29759143
DOI: 10.1016/j.jneuroim.2018.05.002

Abstract

Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

Keywords: GPR109A; Macrophage polarization; Niacin; Parkinson's disease.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Dietary Supplements*
Female
Humans
Macrophages / drug effects
Macrophages / immunology*
Male
Middle Aged
Niacin / pharmacology*
Parkinson Disease / immunology*
Quality of Life*

Substances

Niacin

Grants and funding

I01 RX001613/RX/RRD VA/United States