Molecular interaction studies of some Co(III)-surfactants with the transport protein

Abstract

The present work describes the synthesis and the molecular interaction of two single-chain Co(III)-coordinated surfactant complexes with a plasma protein, human serum albumin by using various biophysical and in silico techniques. The experimental data reveals that like ordinary classical surfactants, our metallosurfactants also have the tendency to associate themselves and form micelles at critical micelle concentration. The thermodynamic parameters (ΔH°, ΔS°, and ΔG°) derived from the experiment demonstrates that the alkyl chain length and the head group of the Co(III)-surfactant complexes played a vital role in the binding process. Both the physico-chemical and computational docking results indicated that the Co(III)-surfactant complexes are stabilized by hydrogen bonding, hydrophobic and/or van der Waals forces. Thus, the data acquired herein for the interesting class of surfactant complexes will be of significance in metal-based drug discovery and developmental research.

Keywords: Bipyridine; Cobalt complex; Metallosurfactant; Phenanthroline; Serum albumin; Spectroscopy.