Abstract
Leukotrienes, a class of arachidonic acid-derived bioactive molecules, are known as mediators of allergic and inflammatory reactions and considered to be important drug targets. Although an inhibitor of leukotriene biosynthesis and antagonists of the cysteinyl leukotriene receptor are clinically used for bronchial asthma and allergic rhinitis, these medications were developed before the molecular identification of leukotriene receptors. Numerous studies using cloned leukotriene receptors and genetically engineered mice have unveiled new pathophysiological roles for leukotrienes. This Review covers the recent findings on leukotriene receptors to revisit them as new drug targets.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arthritis, Experimental / immunology
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Arthritis, Experimental / metabolism
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Asthma / immunology
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Asthma / metabolism
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Atherosclerosis / immunology
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Atherosclerosis / metabolism
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Chemotaxis, Leukocyte / immunology
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Humans
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Leukotriene Antagonists / chemistry
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Leukotriene Antagonists / therapeutic use*
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Mice
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Models, Biological
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Models, Molecular
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Molecular Structure
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Neoplasms / immunology
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Neoplasms / metabolism
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Receptors, Leukotriene / chemistry
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Receptors, Leukotriene / metabolism*
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Receptors, Leukotriene B4 / antagonists & inhibitors
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Receptors, Leukotriene B4 / chemistry
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Receptors, Leukotriene B4 / metabolism
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Signal Transduction
Substances
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LTB4R protein, human
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LTB4R2 protein, human
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Leukotriene Antagonists
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Ltb4r1 protein, mouse
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Ltb4r2 protein, mouse
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Receptors, Leukotriene
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Receptors, Leukotriene B4