Neutrophil-to-lymphocyte ratio as a prognostic factor for pharyngocutaneous fistula after total laryngectomy

F T Aires; R A Dedivitis; M A V Kulcsar; D M Ramos; C R Cernea

doi:10.14639/0392-100X-1572

Neutrophil-to-lymphocyte ratio as a prognostic factor for pharyngocutaneous fistula after total laryngectomy

Acta Otorhinolaryngol Ital. 2018 Feb;38(1):31-37. doi: 10.14639/0392-100X-1572.

Authors

F T Aires¹, R A Dedivitis¹, M A V Kulcsar², D M Ramos², C R Cernea³

Affiliations

¹ Department of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
² Department of Head and Neck Surgery, Instituto do Cancer do Estado de Sao Paulo ICESP, São Paulo, Brazil.
³ Department of Head and Neck Surgery, University of São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil.

Abstract
in English, Italian

The role of systemic inflammatory response as a prognostic factor has been proposed in a variety of cancers. The purpose of this study was to investigate the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the incidence of pharyngocutaneous fistula (PCF) in patients who underwent total laryngectomy. We conducted a retrospective cohort analysis of 141 patients with squamous cell carcinoma of larynx who underwent total laryngectomy from 2009 to 2015. The incidence of PCF was 49.6%. A higher risk of 23% was observed among patients with NLR > 2.5 for the occurrence of PCF (p = 0.007). Patients with laryngeal squamous cell carcinoma who present elevated values in the ration > LR> (> 2.5) presented a higher risk of developing pharyngocutaneous fistula in the postoperative setting of total laryngectomy.

Rapporto neutrofili-linfociti come fattore prognostico per le fistole faringocutanee dopo laringectomia totale.

Riassunto: Il ruolo della risposta infiammatoria sistemica come fattore prognostico è stato già proposto per molti tipi di tumore. Lo scopo di questo studio è stato quello di definire il valore prognostico del rapporto neutrofili-linfociti (NLR) pretrattamento come fattore di rischio per la fistola faringocutanea (PFC) in pazienti sottoposti a laringectomia totale. Abbiamo quindi analizzato retrospettivamente 141 pazienti con carcinoma squamoso della laringe trattati con laringectomia totale tra il 2009 e il 2015. L’incidenza d PCF è stata pari a 49,6%. In particolare, è stato osservato un rischio maggiore di sviluppare PFC, di circa il 23%, nei pazienti con NLR > 2,5 (p = 0,007). in conclusione, i pazienti con carcinoma squamoso della laringe con un elevato rapporto neutrofili-linfociti (> 2,5) presentano un maggiore rischio di sviluppare fistole faringocutanee nel post-operatorio della laringectomia totale.

Keywords: Cutaneous fistula; Laryngeal neoplasms; Postoperative complications; Squamous cell carcinoma.

Publication types

Observational Study

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / surgery
Cohort Studies
Cutaneous Fistula / blood*
Cutaneous Fistula / epidemiology
Female
Fistula / blood*
Fistula / epidemiology
Humans
Incidence
Laryngeal Neoplasms / surgery
Laryngectomy*
Leukocyte Count
Lymphocyte Count
Lymphocytes*
Male
Middle Aged
Neutrophils*
Pharyngeal Diseases / blood*
Pharyngeal Diseases / epidemiology
Postoperative Complications / blood*
Predictive Value of Tests
Prognosis
Retrospective Studies

Abstract in English, Italian

Publication types

MeSH terms

Abstract
in English, Italian