An amplified chemiluminescence system based on Si-doped carbon dots for detection of catecholamines

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Aug 5:201:223-228. doi: 10.1016/j.saa.2018.04.058. Epub 2018 Apr 30.

Abstract

We report on a chemiluminescence (CL) system based on simultaneous enhancing effect of Si-doped carbon dots (Si-CDs) and cetyltrimethylammonium bromide (CTAB) on HCO3--H2O2 reaction. The possible CL mechanism is investigated and discussed. Excited-state Si-CDs was found to be the final emitting species, which are probably produced via electron and hole injection by oxy-radicals. The effect of several other heteroatom-doped CDs and undoped CDs was also investigated and compared with Si-CDs. Furthermore, it was found that catecholamines such as dopamine, adrenaline and noradrenaline remarkably diminish the CL intensity of Si-CD-HCO3--H2O2-CTAB system. By taking advantage of this fact, a sensitive probe was designed for determination of dopamine, adrenaline and noradrenaline with a limit of detection of 0.07, 0.60 and 0.01 μM, respectively. The method was applied to the determination of catecholamines in human plasma samples.

Keywords: Carbon nanomaterials; Catecholamines; Chemiluminescence; Si-doped carbon dots; Surfactant.

MeSH terms

  • Carbon / chemistry
  • Catecholamines / blood*
  • Cetrimonium
  • Cetrimonium Compounds / chemistry
  • Humans
  • Limit of Detection
  • Linear Models
  • Luminescent Measurements / methods*
  • Nanostructures / chemistry*
  • Reproducibility of Results
  • Silicon / chemistry
  • Surface-Active Agents / chemistry

Substances

  • Catecholamines
  • Cetrimonium Compounds
  • Surface-Active Agents
  • Carbon
  • Silicon
  • Cetrimonium