Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings

Annapoorna Mohandas; S Deepthi; Raja Biswas; R Jayakumar

doi:10.1016/j.bioactmat.2017.11.003

Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings

Bioact Mater. 2017 Nov 24;3(3):267-277. doi: 10.1016/j.bioactmat.2017.11.003. eCollection 2018 Sep.

Authors

Annapoorna Mohandas¹, S Deepthi¹, Raja Biswas¹, R Jayakumar¹

Affiliation

¹ Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, 682 041, India.

Abstract

Chitosan based nanocomposite scaffolds have attracted wider applications in medicine, in the area of drug delivery, tissue engineering and wound healing. Chitosan matrix incorporated with nanometallic components has immense potential in the area of wound dressings due to its antimicrobial properties. This review focuses on the different combinations of Chitosan metal nanocomposites such as Chitosan/nAg, Chitosan/nAu, Chitosan/nCu, Chitosan/nZnO and Chitosan/nTiO₂ towards enhancement of healing or infection control with special reference to the antimicrobial mechanism of action and toxicity.

Keywords: Antimicrobial Chitosan nanocomposities; Copper; Gold; Silver; Wound healing; Zinc oxide.

Publication types

Review