Abstract
Two new polyketide metabolites, the 12-membered macrolides 4-hydroxy-12-methyloxacyclododecane-2,5,6-trione (1) and 12-methyloxacyclododecane-2,5,6-trione (2), were isolated from the endophytic fungal strain Cladosprium colocasiae A801 of the plant Callistemon viminalis, together with five known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. The antibacterial, cytotoxic, and α-glucosidase inhibitory activities of the new compounds 1 and 2 were evaluated.
Keywords:
bioactivity assay; chemical constituents; endophytic fungus.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Ascomycota / chemistry*
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Bacteria / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Endophytes / chemistry*
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Fermentation
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Glucosidases / antagonists & inhibitors
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Humans
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Macrolides / chemistry*
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Macrolides / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Myrtaceae / chemistry*
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Myrtaceae / microbiology
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Antineoplastic Agents, Phytogenic
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Macrolides
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Glucosidases