Cytotoxic garcimultiflorones K-Q, lavandulyl benzophenones from Garcinia multiflora branches

Abstract

Seven undescribed lavandulyl benzophenones garcimultiflorones K-Q, and fourteen known compounds were isolated from the CHCl₃ soluble fraction of 95% EtOH extract of Garcinia multiflora branches. Their structures and absolute configurations were determined by spectroscopic techniques including NMR spectroscopy, MS analysis, and ECD calculations. Seven isolated compounds expect for garcimultiflorone L and garcimultiflorone O exhibited cytotoxic activities in vitro against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480). It is worth mentioning that garcimultiflorone Q exhibited most significant cytotoxicities against five cancer cell lines with IC₅₀ values ranging from 3.07-12.56 μM.

Keywords: Benzophenones; Clusiaceae; Cytotoxicity; Garcinia multiflora; Lavandulyl derivatives.