Objective: To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility.
Methods: We searched Pubmed, EMBASE, Web of Science, CNKI, and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time. According to the inclusion criteria, we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software.
Results: A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies. The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model, hybrid comparison model and dominant comparison model), with the pooled odds ratios (OR) of 1.26 (95% CI: 1.03－1.54, P = 0.023), 1.18 (95% CI: 1.03－1.36, P = 0.018), and 1.20 (95% CI: 1.05－1.37, P = 0.006), respectively. And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models, with the pooled ORs of 1.24, (95% CI: 1.05－1.45, P = 0.009) and 1.20 (95% CI: 1.04－1.39, P = 0.013), respectively. Layered meta-analysis showed that in the homozygous comparison model, the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population, with the OR of 1.37 (95% CI: 1.03－1.82, P = 0.003) and 1.21 (95% CI: 1.00－1.47, P = 0.048), respectively.
Conclusions: In the homozygous model (GG vs AA), the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility.
目的: 用Meta分析的方法综合评价FSHR Thr307Ala-Asn680Ser等位基因多态性与男性不育的关联性。方法： 检索PubMed、EMBASE、Web of Science、中国知网和万方等中英文数据库2005至今文献，依据选择标准收集相关病例对照研究数据，应用Stata 11.0软件对符合条件的研究结果进行Meta分析。 结果: 符合纳入标准的共12篇文献，包含病例组2 893例和对照组3 312例。经综合分析：在3种比较模型（纯合比较模型、杂合比较模型和显性比较模型）中，Thr307Ala(rs6165)位点多态性是男性不育的危险因素，OR值分别为1.26（95% CI:1.03~1.54）, P = 0.023； 1.18（95% CI: 1.03~1.36）, P=0.018；1.20（95% CI:1.05~1.37），P = 0.006）。而Asn680Ser(rs6166) 位点多态性在两种比较模型（纯合比较模型和隐性比较模型），是男性不育的危险因素，OR值分别为1.24（95% CI:1.05~1.45）, P = 0.009；1.20（95% CI = 1.04~1.39）, P = 0.013。 分层Meta分析结果则表明，在纯合比较模型中，Thr307Ala和Asn680Ser位点多态性在白种人群中是男性不育的危险因素，OR值分别为1.37（95% CI:1.03~1.82），P = 0.003；1.21（95% CI:1.00~1.47）, P = 0.048。结论: 在纯合比较模型中，FSHR Thr307Ala 和Asn680Ser位点多态性可能是男性不育发生的影响因素之一。.
Keywords: Asn680Ser; FHS receptor; Thr307Ala; gene polymorphism; meta-analysis; male infertility.