Abstract
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has proved to be an active agent against S. aureus Here, the in vitro activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA isolates revealing its high activity against mecA-, mecB-, and mecC-positive LA-MRSA.
Keywords:
LA-MRSA; Staphylococcus aureus; antimicrobial agents; bacteriophage therapy; endolysin; livestock; susceptibility testing.
Copyright © 2018 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphatases / genetics
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Animals
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacteriophages / metabolism*
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Endopeptidases / pharmacology*
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Humans
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Livestock
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Microbial Sensitivity Tests
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Penicillin-Binding Proteins / genetics
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Recombinant Proteins / pharmacology*
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / veterinary
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Penicillin-Binding Proteins
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Recombinant Proteins
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mecA protein, Staphylococcus aureus
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Endopeptidases
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HY-133
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endolysin
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Adenosine Triphosphatases