Fornical Closed-Loop Stimulation for Alzheimer's Disease

Suhan Senova; Antoine Chaillet; Andres M Lozano

doi:10.1016/j.tins.2018.03.015

Fornical Closed-Loop Stimulation for Alzheimer's Disease

Trends Neurosci. 2018 Jul;41(7):418-428. doi: 10.1016/j.tins.2018.03.015. Epub 2018 May 4.

Authors

Suhan Senova¹, Antoine Chaillet², Andres M Lozano³

Affiliations

¹ Krembil Research Institute, University Health Network, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Centre, University Health Network, University of Toronto, Toronto, ON, Canada; Departments of Neurosurgery and Psychiatry, Assistance Publique-Hôpitaux de Paris (APHP) Groupe Henri-Mondor Albert-Chenevier, 94000 Créteil, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 955, Mondor Institute of Biomedical Research (IMRB), Faculté de Médecine, Université Paris 12, Université Paris-Est Créteil (UPEC), 94010 Créteil, France. Electronic address: yann.senova@aphp.fr.
² Laboratoire des Signaux et Systèmes (L2S), CentraleSupélec, Université Paris Sud, Centre National de la Recherche Scientifique (CNRS), Université Paris Saclay, 91192 Gif-sur-Yvette, France; Junior member of Institut Universitaire de France (IUF), Junior member of Institut Universitaire de France (IUF), 91192.
³ Krembil Research Institute, University Health Network, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Centre, University Health Network, University of Toronto, Toronto, ON, Canada.

PMID: 29735372
DOI: 10.1016/j.tins.2018.03.015

Abstract

Pharmacological neuromodulation strategies have shown limited efficacy in treating memory deficits related to Alzheimer's disease (AD). Despite encouraging results from a few preclinical studies, clinical trials investigating open-loop deep brain stimulation (DBS) for AD have not been successful. Recent refinements in understanding the various phases of memory processes, animal studies investigating phase-specific modulation of hippocampal activity during memorization, and clinical studies using closed-loop DBS strategies to treat patients with movement disorders, all point to the need to investigate closed-loop fornical DBS strategies to better understand memory dynamics and potentially treat memory deficits in AD preclinical models.

Keywords: Alzheimer’s disease; closed-loop; deep brain stimulation; fornix.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / physiopathology
Alzheimer Disease / therapy*
Animals
Deep Brain Stimulation / methods*
Fornix, Brain* / physiopathology
Humans