Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

Haiyan Wu; Chen-Jung Lee; Huifeng Wang; Yang Hu; Megan Young; Yu Han; Fu-Jian Xu; Hongbo Cong; Gang Cheng

doi:10.1039/c7sc05104b

Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

Chem Sci. 2018 Jan 24;9(9):2540-2546. doi: 10.1039/c7sc05104b. eCollection 2018 Mar 7.

Authors

Haiyan Wu¹, Chen-Jung Lee¹, Huifeng Wang², Yang Hu², Megan Young², Yu Han³, Fu-Jian Xu⁴, Hongbo Cong¹, Gang Cheng²

Affiliations

¹ Department of Chemical and Biomolecular Engineering , University of Akron , Akron , Ohio 44325 , USA . Email: hcong@uakron.edu ; http://www.uakron.edu/engineering/about-us/people-directory/bio-detail.dot?u=hcong.
² Department of Chemical Engineering , University of Illinois at Chicago , Chicago , Illinois 60607 , USA . Email: gancheng@uic.edu ; https://che.uic.edu/k-teacher/gang-cheng-ph-d/.
³ Department of Mechanical Engineering , University of Akron , Akron , Ohio 44325 , USA.
⁴ Key Laboratory of Carbon Fiber and Functional Polymers (Ministry of Education) , Beijing Laboratory of Biomedical Materials , Beijing University of Chemical Technology , Beijing 100029 , China.

Abstract

A zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT)-based glucose biosensor was fabricated via encapsulating glucose oxidase (GOx) in a one-step electropolymerization method. Integrating conductivity and hydrophilic properties, PSBEDOT provides a great framework for GOx immobilization and stabilization. The anti-fouling, high-sensitivity, and long-term stability properties of PSBEDOT-GOx make it a promising platform for long-term and continuous glucose monitoring.