To Claim Growth Turf, mTOR Says SOD Off

Hyewon Kong; Navdeep S Chandel

doi:10.1016/j.molcel.2018.04.015

To Claim Growth Turf, mTOR Says SOD Off

Mol Cell. 2018 May 3;70(3):383-384. doi: 10.1016/j.molcel.2018.04.015.

Authors

Hyewon Kong¹, Navdeep S Chandel²

Affiliations

¹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
² Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: nav@northwestern.edu.

PMID: 29727615
DOI: 10.1016/j.molcel.2018.04.015

Abstract

Maintaining redox balance in cancer cells is essential for tumor development and progression. In this issue of Molecular Cell, Tsang et al. (2018) identify an evolutionarily conserved mTORC1-dependent mechanism by which cancer cells control redox homeostasis in ischemic tumor microenvironment.

Publication types

Comment

MeSH terms

Mechanistic Target of Rapamycin Complex 1*
Nutrients*
Oxidation-Reduction
Phosphorylation
Signal Transduction
Superoxide Dismutase-1
TOR Serine-Threonine Kinases

Substances

Superoxide Dismutase-1
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases

Grants and funding

T32 CA009560/CA/NCI NIH HHS/United States