Objective: To investigate the association of the abnormal length of human Y chromosome with semen quality and the outcome of assisted reproductive technology (ART).
Methods: Based on the karyotype, we assigned the patients undergoing ART to a normal control, a long Y chromosome (Y>18), and a short Y chromosome group (Y<22). We compared the semen parameters and numbers of embryos and high-quality embryos among the three groups of patients and performed statistical analysis of the obtained data using Chi-square distribution and t-test.
Results: Compared with the control, the Y>18 group showed a significantly lower incidence rate of asthenozoospermia (31.03% vs 8.33%, P <0.05) and a larger number of high-quality embryos (5.46 ± 4.54 vs 7.40 ± 5.49, P<0.05). Both the incidence rate of azoospermia and number of total embryos were remarkably lower in the control than in the Y<22 group (1.87% vs 16.47%, P <0.05; 8.60 ± 7.03 vs 10.00 ± 6.58, P<0.05). No statistically significant differences were found in the pregnancy rate between the Y>18 and Y<22 groups (P>0.05).
Conclusions: Short Y chromosome may affect spermatogenesis, but the length of Y chromosome does not negatively influence the outcome of ART.
目的： 探讨Y染色体长度异常对精液参数以及对ART结局的影响，以期为临床工作提供指导。方法： 963例辅助生育患者按Y染色体长度分为正常对照组(n=854)，Y>18组(n=24)及Y<22组(n=85)，并将Y>18组和Y<22组的精液参数及在ART过程中的胚胎数及优质胚胎数与正常对照组进行比较。用χ2检验及t检验进行统计学分析。结果： Y>18组中弱精子症患者比例明显低于正常对照组(8.33% vs 31.03%)，优质胚胎数较对照组多，差异均有显著性（P<0.05）；Y<22组中无精子症比例明显高于正常对照组(16.47% vs 1.87%)，在ICSI过程中胚胎数多于正常对照组，差异均有显著性（P<0.05），Y>18和Y<22两组妊娠率与对照组统计学差异均无显著性（P>0.05）。结论： 小Y染色体可能对精子发生有影响，而携带大、小Y染色体不会降低ART的妊娠率。因此，对于大、小Y染色体携带不育患者，进行辅助生殖技术可获得和正常核型类似的妊娠结局。.
Keywords: outcome of assisted reproductive technology; semen parameters; long and short Y chromosomes.