Prostaglandin synthase (PGS) can catalyze the production of various types of prostaglandins and regulate the expression levels of related substances. The regulation mechanisms of the PGS gene are closely related with the occurrence and development of prostate diseases. However, few studies are reported on the regulation mechanisms of PGS in prostatic diseases, such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa), or on the relationship between PGS gene regulation and prostate diseases. This review aims to analyze their correlation and provide some ideas for the prevention and control of BPH and PCa by intervention of the prostaglandin synthase regulatory pathway.
前列腺素合成酶（PGS）能催化各种类型前列腺素的生成，调节相关物质的基因表达水平，其基因调控机制与前列腺疾病的发生和发展密切相关。目前有关PGS在前列腺疾病如良性前列腺增生（BPH）和前列腺癌（PCa）中调控机制的研究很少，鲜有研究直接对PGS基因调控与前列腺疾病关系进行探讨。本文拟对两者的关系进行分析，为从干预PGS调控途径防控BPH和PCa提供研发思路。.
Keywords: benign prostatic hyperplasia; gene regulation; prostate cancer; prostaglandin synthase.