A self-assembly nanocomposite was designed to mimic intracellular enzymatic and non-enzymatic antioxidants-constituted antioxidant defense machinery. In this work, selenium nanocomponent served as one model to mimic antioxidant enzyme, whereas polydopamine was able to mimic non-enzymatic antioxidant biomolecule in living systems. With the excellent glutathione peroxidase-mimic capacity of selenium and the reducibility of polydopamine, this Se@pDA nanozyme could achieve synergetic antioxidative efficiency to protect cellular components against oxidative damage. The pneumonia model of mice further proved the potential of our nanocomposites for anti-inflammation therapy.
Keywords: antioxidant machinery; enzymes; nanozymes; reactive oxygen species; self-assembly.
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