Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1

Laura Ciarlo; Rosa Vona; Valeria Manganelli; Lucrezia Gambardella; Carla Raggi; Matteo Marconi; Walter Malorni; Maurizio Sorice; Tina Garofalo; Paola Matarrese

doi:10.18632/oncotarget.24792

Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1

Oncotarget. 2018 Apr 10;9(27):18869-18884. doi: 10.18632/oncotarget.24792.

Authors

Affiliations

¹ Oncology Unit, Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.
² Department of Experimental Medicine, Sapienza University, Rome, Italy.
³ Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
⁴ Center of Metabolomics, Rome, Italy.

Abstract

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and their homeostasis.

Keywords: apoptosis; fusion; lipid rafts; mitochondria; reactive oxygen species.