Objective: To assess the clinical efficacy of the saw palmetto fruit extract (SPFE) in the treatment of lower urinary tract symptoms (LUTS) in patients with type ⅢA prostatitis.
Methods: This retrospective study included 54 cases of type ⅢA prostatitis treated in the Outpatient Department of our hospital from January to December 2015. The patients were aged 35.06 ± 5.85 years, with a mean disease course of 3.8 ± 2.1 years, and all received oral medication of SPFE Capsules at the dose of 320 mg qd for 12 weeks. We assessed the therapeutic effects by comparing the NIH-chronic prostatitis symptom indexes (NIH-CPSI), voiding diary, International Prostate Symptom Scores (IPSS), and results of urodynamic examination before and after treatment.
Results: Compared with the baseline, both NIH-CPSI and IPSS were significantly decreased after medication (27.61 ± 3.76 vs 18.6 ± 5.34, P <0.01; 20.44 ± 4.51 vs 10.96±4.62, P <0.01), and urodynamic examination and voiding diary showed dramatic post-medication improvement in the average urinary flow rate (［8.05±1.42］ vs ［12.05±2.60］ ml/s, P <0.01 ), maximum urinary flow rate (［14.22±1.74］ vs ［21.32±4.51］ ml/s, P <0.01), residual urine volume (［46.15±16.57］ vs ［14.55±10.21］ ml, P <0.01), maximum urethral closure pressure (［76.52±3.53］ vs ［65.32±4.75］ cm H2O, P <0.01), mean urinary volume (［124.63±40.55］ vs ［285.93±58.68］ ml, P <0.01), urination frequency (16.96±4.17 vs 8.96±2.50, P <0.01), and nocturia frequency (8.94±3.23 vs 3.15±1.90, P <0.01). No apparent adverse reactions were observed in any of the patients.
Conclusions: SPFE Capsules can safely and effectively improve LUTS and thus the quality of life of patients with type ⅢA prostatitis.
目的： 探讨锯叶棕果实提取物对以下尿路症状（LUTS）为主要症状的ⅢA型前列腺炎治疗的临床疗效。方法： 对2015年1月至12月就诊的54例ⅢA型前列腺炎患者予以锯叶棕果实提取物软胶囊口服320 mg/次，1次/d，12周后评价疗效。使用慢性前列腺炎症状指数（NIH-CPSI）评分、排尿日记及国际前列腺症状（IPSS）评分评估治疗前后症状，并行尿动力学检查，比较患者治疗前后变化。结果： 治疗12周后，患者的NIH-CPSI评分（18.6±5.34）较治疗前（27.61±3.76）明显下降（P<0.01）、IPSS评分（10.96±4.62）较治疗前（20.44±4.51）有明显下降（P<0.01）。尿动力学检查指标反应治疗前平均尿流率［AFR(8.05±1.42) ml/s］、最大尿流率［MFR(14.22±1.74) ml/s］、残余尿［RU(46.15±16.57) ml］、尿道最大闭合压［MCP(76.52±3.53) cmH2O］，治疗后指标［AFR(12.05±2.60) ml/s、MFR(21.32±4.51) ml/s、RU(14.55±10.21) ml、MCP(65.32±4.75) cmH2O］均明显改善（P<0.01）。排尿日记显示治疗后平均排尿量［（285.93±58.68) ml］、排尿次数（8.96±2.50）及夜尿次数（3.15±1.90）次均较治疗前［（124.63±40.55) ml、16.96±4.17、8.94±3.23］明显改善（P<0.01）。治疗期间所有患者均未诉不良反应。结论： 锯叶棕果实提取物可有效地改善ⅢA型前列腺炎患者出现的LUTS，提高患者生活质量，且安全性高，可作为临床治疗方案之一。.
Keywords: low urinary tract symptoms; saw palmetto fruit extract; urodynamic examination; ⅢA prostatitis.