Abstract
A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.
MeSH terms
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Animals
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Bridged-Ring Compounds / pharmacology*
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Disease Models, Animal
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Imidazoles / pharmacology*
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Larva
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Mice
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Mice, Inbred C57BL
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Molecular Structure
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Neuroprotective Agents / pharmacology*
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Pentylenetetrazole / adverse effects
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Seizures / chemically induced
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Seizures / drug therapy*
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Zebrafish
Substances
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Bridged-Ring Compounds
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Imidazoles
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Neuroprotective Agents
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cucurbit(7)uril
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Pentylenetetrazole