[Establishing a screening programme in Denmark for foetal and neonatal alloimmune thrombocytopenia]

Ugeskr Laeger. 2018 Apr 23;180(17):V03170211.
[Article in Danish]

Abstract

Foetal and neonatal alloimmune thrombocytopenia (FNAIT) can cause cerebral haemorrhage in newborns. FNAIT occurs in women, who do not have the thrombocyte type human platelet antigen (HPA)-1a and are carrying an HPA-1a positive foetus. Maternal antibodies can cause thrombocytopenia in the foetus or newborn. Antenatal screening for FNAIT can easily be integrated in the already existing national screening programme for rhesus immunisation. Prophylactic treatment with immunoglobulines for pregnancies at risk can prevent neonatal complications. We argue, that the WHO criteria for a screening programme for FNAIT are met.

Publication types

  • Review

MeSH terms

  • Cerebral Hemorrhage / genetics
  • Denmark
  • Diagnostic Screening Programs / standards*
  • Female
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Trimester, First
  • Pregnancy, High-Risk
  • Prenatal Diagnosis
  • Thrombocytopenia, Neonatal Alloimmune* / diagnosis
  • Thrombocytopenia, Neonatal Alloimmune* / prevention & control
  • Thrombocytopenia, Neonatal Alloimmune* / therapy
  • World Health Organization