Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris

Phytochemistry. 2018 Aug:152:10-21. doi: 10.1016/j.phytochem.2018.04.012. Epub 2018 Apr 30.

Abstract

Fifteen undescribed and five known lanostane-type C31 triterpenoid derivatives were isolated from the aqueous EtOH extract of the fruiting bodies of cultivated Fomitopsis palustris. Their structures were identified from the spectroscopic data and chemical degradation studies. The structures of palustrisoic acids A and H were confirmed by X-ray crystallography. Polyporenic acid B showed strong cytotoxicity against the HCT116, A549, and HepG2 cell lines with IC50 values of 8.4, 12.1, and 12.2 μM, respectively. Palustrisolides A, C, and G displayed weak cytotoxicity.

Keywords: Cytotoxicity; Fomitopsidaceae; Fomitopsis palustris; Lanostane; Palustrisoic acid; Palustrisolide; Triterpenoid.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Coriolaceae / chemistry*
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Fruiting Bodies, Fungal / chemistry*
  • HCT116 Cells
  • Hep G2 Cells
  • Humans
  • Hydrolysis
  • Models, Molecular
  • Molecular Structure
  • Sodium Hydroxide / chemistry
  • Structure-Activity Relationship
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Terpenes
  • Sodium Hydroxide